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Sildenafil was damaging in in Chinese hamster cell assays and vitro microbial to identify in human lymphocytes, as well as mutagenicity assays to detect. There is no disability of fertility in rodents provided sildenafil as much as 60 kg/evening for 102 times to guys and 36 times to women, a dosage creating an AUC worth greater than 25 times the individual AUC that is male. No proof of embryotoxicity, teratogenicity or fetotoxicity was seen in rabbits and rodents which obtained as much as 200 mg/ kg during organogenesis. These amounts signify, respectively, about 20 and 40 occasions the Most Proposed Individual Dosage (MRHD) on the mg/m² foundation in a-50 kg topic. In pre-and postnatal growth research, the undesirable impact dosage that is number observed was 30 mg/kg/evening provided for 36 times. Within the rat the AUC only at that dosage was about 20 times AUC that is individual.

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