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In another medication interaction research, when amlodipine, 5 mg or 10 mg, and VIAGRA, 100 mg were orally given concomitantly to hypertensive individuals imply extra blood-pressure reduced amount of 8 mmHg systolic and 7 mmHg diastolic were mentioned [notice DRUG RELATIONSHIPS and CLINICAL PHARMACOLOGY ]. The concomitant management of the protease inhibitor ritonavir significantly raises serum levels of sildenafil (11-fold increase in AUC). Warning ought to be utilized if VIAGRA is recommended to sufferers using ritonavir. Information from themes subjected to large endemic degrees of sildenafil are restricted. Reduced blood-pressure, syncope, and extended impotence were documented in certain healthy volunteers subjected to large amounts of sildenafil (200-800 mg). To diminish adverse reactions' opportunity in-patients using ritonavir, there is in sildenafil dose a reduction preferred [view CLINICAL AND ADMINISTRATION and DOSAGE ].

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