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Doctors must notify individuals to not consider VIAGRA with additional PDE5 inhibitors including REVATIO or additional pulmonary arterial hypertension (PAH) remedies containing sildenafil. Sildenafil can also be promoted for that cure of PAH as REVATIO. The security and effectiveness of including REVATIO, VIAGRA with other inhibitors, haven't been analyzed [view WARNINGS ]. The usage of VIAGRA provides no safety against sexually transmitted diseases. Guidance of sufferers concerning the defensive steps essential to shield against sexually transmitted illnesses, such as the Human Immunodeficiency Disease (HIV), might be regarded [view WARNINGS AND PRECAUTIONS ]. Sildenafil wasn't carcinogenic when given to rats for two years in a dosage leading to complete endemic medication publicity (AUCs) for unbound sildenafil and its own main metabolite of 29-and 42-occasions, for man and female rodents, respectively, the exposures seen in individual guys provided the Most Proposed Individual Dosage (MRHD) of 100-mg. Sildenafil wasn't carcinogenic when given to rodents for 18-21 weeks at doses as much as the Most Tolerated Dose (MTD) of 10 mg/kg/evening, roughly 0.6 occasions the MRHD on the mg/m² foundation.

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